IGF‑DES (1–3) – 2mg

Permagainz IGF-DES (1–3) is a synthetic truncated analogue of Insulin-Like Growth Factor-1 (IGF-1) supplied exclusively for in-vitro and laboratory research.

This peptide represents a modified version of human IGF-1 lacking the first three N-terminal amino acids, which alters its receptor-binding dynamics and increases biological potency in controlled experimental conditions.

Each vial contains 2 mg of lyophilised IGF-DES, produced under ISO-certified sterile conditions to guarantee reproducibility, purity, and traceable analytical integrity.

Chemical Background / Research Profile

The chemical formula of IGF-DES (1–3) is C₃₃₂H₅₁₅N₉₇O₉₈S₇, with a molecular weight of approximately 7,346 g/mol.

This truncated peptide analogue is used to study growth factor signalling, cell proliferation, and receptor-ligand interactions in laboratory systems.

In vitro, IGF-DES (1–3) is often employed to:

• Investigate IGF-1 receptor binding kinetics and downstream PI3K/AKT and MAPK pathway signalling.

• Examine mitogenic and metabolic responses in cultured cell lines.

• Evaluate structural and stability differences between full-length IGF-1 and its shortened derivative.

By removing the first three N-terminal amino acids, IGF-DES demonstrates altered receptor affinity and reduced binding to IGF-binding proteins (IGFBPs), making it a valuable tool for controlled receptor and signal-pathway studies in cell-based assays.

Purity and Quality Assurance

Permagainz IGF-DES is manufactured to ≥ 98 % purity, verified by High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) testing.
All manufacturing occurs within ISO-accredited laboratories following Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) guidelines.

Each vial is sterile-sealed, batch-coded, and supplied with a Certificate of Analysis (CoA) confirming molecular structure, purity, batch number, and expiry date for traceability and compliance.

Laboratory Handling and Storage

• Store at 2–8 °C, protected from light and moisture.

• For extended preservation, freeze at –20 °C.

• Allow the vial to reach ambient temperature before opening to prevent condensation.

• Reconstitute with sterile bacteriostatic water or an equivalent laboratory-grade solvent under aseptic conditions.

• Avoid repeated freeze–thaw cycles and dispose of unused solutions in accordance with institutional chemical and biosafety guidelines.

All peptide handling should be carried out using standard laboratory PPE (gloves, lab coat, and protective eyewear) within controlled research facilities.

Safety, Compliance and Restrictions

IGF-DES (1–3) is not a pharmaceutical, not approved for human or veterinary use, and must not be administered, consumed, or applied therapeutically.
It is supplied strictly for research and in-vitro scientific purposes only.

Permagainz operates in full compliance with MHRA, REACH, and COSHH regulations covering research-only chemical substances.

All peptides are batch-verified, properly labelled, and accompanied by relevant documentation for laboratory traceability.

By maintaining rigorous analytical validation and sterile production standards, Permagainz provides researchers with a consistent, high-integrity IGF-DES (1–3) product suitable for reliable, reproducible study of peptide-mediated cellular mechanisms.