IGF1-LR3 1MG

Permagainz IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1) is a synthetic recombinant peptide analogue of human IGF-1, designed for in-vitro and laboratory research applications.
This extended form of IGF-1 contains an additional 13 amino acids, including a substitution of arginine for glutamic acid at position 3, resulting in reduced affinity for IGF-binding proteins and enhanced receptor interaction during scientific assays.

Each vial contains 1 mg of lyophilised IGF-1 LR3, manufactured in ISO-certified facilities under sterile, controlled conditions to maintain high purity and analytical reliability.

Chemical Background / Research Profile

The chemical formula of IGF-1 LR3 is C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉, with a molecular weight of approximately 9,111 g/mol.
It is a 83-amino-acid single-chain polypeptide analogue of human IGF-1, modified to resist enzymatic degradation and maintain bioactivity over extended periods in laboratory models.

In research settings, IGF-1 LR3 is used to study:

• IGF-1 receptor (IGF-1R) binding and signalling kinetics.

• Cellular proliferation, differentiation, and survival mechanisms.

• Protein synthesis and metabolism in cultured cells.

• Peptide stability and bioavailability in vitro compared to native IGF-1.

Because of its reduced binding affinity to IGF-binding proteins (IGFBPs), IGF-1 LR3 provides researchers with a reproducible model to explore growth factor signalling, insulin-like peptide function, and cellular response mechanisms under controlled laboratory conditions.

Purity and Quality Assurance

All Permagainz peptides are manufactured to ≥ 98 % purity, verified by High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).
Production adheres to Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) standards in ISO-accredited facilities.
Each vial is sterile-sealed, clearly labelled, and supplied with a Certificate of Analysis (CoA) confirming molecular integrity, batch number, and expiry date for full traceability and compliance.

Laboratory Handling and Storage

• Store at 2–8 °C, protected from light and moisture.

• For long-term storage, freeze at –20 °C.

• Allow vial to reach room temperature before opening to prevent condensation.

• Reconstitute using sterile bacteriostatic water or another approved laboratory solvent under aseptic conditions.

• Avoid repeated freeze–thaw cycles.

• Dispose of any unused solution in accordance with institutional chemical and biosafety policies.

All handling must be conducted within authorised laboratory environments using appropriate PPE (gloves, lab coat, and protective eyewear).

Safety, Compliance and Restrictions

IGF-1 LR3 is not a pharmaceutical, not approved for human or veterinary use, and must not be administered, consumed, or used for diagnostic or therapeutic purposes.

It is supplied strictly for laboratory and in-vitro scientific research.
Permagainz operates in full accordance with MHRA, REACH, and COSHH safety and regulatory standards for non-medicinal chemical materials.

Through rigorous analytical verification, batch documentation, and sterile production, Permagainz provides IGF-1 LR3 of exceptional purity and reliability—supporting reproducible research into growth factor biology and cellular signal transduction.