MOTS‑C 10mg

Permagainz MOTS-C is a synthetic mitochondrial-derived peptide (MDP) supplied strictly for in-vitro and laboratory research.
This 16-amino-acid peptide, encoded by the mitochondrial 12S rRNA gene, is of growing interest in molecular biology for its role in studies involving cellular metabolism, AMPK activation, mitochondrial signalling, and metabolic regulation.

Each vial contains 10 mg of lyophilised MOTS-C, produced in ISO-certified clean-room environments under sterile conditions to guarantee analytical integrity, reproducibility, and high purity.

Chemical Background / Research Profile

The chemical formula of MOTS-C is C₉H₂₆N₁₄O₁₀S, with a molecular weight of approximately 2,047 g/mol.

It is a 16-amino-acid peptide with the sequence MRWQEMGYIFYPRKLR, discovered as part of a class of mitochondrial-encoded peptides involved in metabolic homeostasis.

In laboratory research, MOTS-C is studied to:

• Explore AMP-activated protein kinase (AMPK) pathway activation in vitro.

• Examine cellular stress responses and metabolic reprogramming.

• Investigate nuclear–mitochondrial communication and peptide transport mechanisms.

• Assess peptide stability and degradation kinetics under controlled experimental conditions.

Because of its regulatory effects on energy signalling in research models, MOTS-C provides valuable insights into cellular bioenergetics and mitochondrial peptide function within molecular biology and biochemistry studies.

Purity and Quality Assurance

Each batch of Permagainz MOTS-C is validated to ≥ 98 % purity, confirmed through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) analysis.

Manufacturing follows Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) standards in ISO-accredited facilities.

Each vial is sterile-sealed and supplied with a Certificate of Analysis (CoA) specifying batch number, purity level, molecular data, and expiry date, ensuring full traceability and compliance for research documentation.

Laboratory Handling and Storage

• Store at 2–8 °C, protected from light and humidity.

• For long-term preservation, freezing at –20 °C is recommended.

• Allow vial to reach ambient temperature before opening to prevent condensation.

• Reconstitute using sterile bacteriostatic water or another suitable laboratory solvent under aseptic conditions.

• Avoid repeated freeze–thaw cycles and discard any unused solution according to institutional biosafety guidelines.

Researchers should use standard PPE—gloves, laboratory coat, and protective eyewear—when handling all peptide materials in controlled laboratory environments.

Safety, Compliance and Restrictions

MOTS-C is not a medicinal product, not approved for human or veterinary use, and must not be ingested, injected, or used for therapeutic or diagnostic purposes.

It is supplied solely for scientific and in-vitro research by qualified professionals.

Permagainz operates under full compliance with MHRA, REACH, and COSHH standards governing non-medicinal research chemical distribution.

All products are batch-tested, traceable, and packaged with supporting documentation to ensure quality and regulatory conformity.

Through stringent analytical testing and transparent manufacturing, Permagainz provides MOTS-C 10 mg as a consistent, high-integrity research peptide ideal for the investigation of mitochondrial signalling, energy metabolism, and peptide-based molecular communication.