N‑Acetyl Epitalon Amidate (NAC form) – 5mg

Permagainz N-Acetyl Epitalon Amidate (NAC form) is a synthetic tetrapeptide derivative supplied exclusively for in-vitro and laboratory research.

It is a stabilised analogue of Epitalon (Ala-Glu-Asp-Gly), modified by N-terminal acetylation and C-terminal amidation to enhance peptide resistance to enzymatic degradation and improve molecular stability during experimental use.

Each vial contains 5 mg of lyophilised N-Acetyl Epitalon Amidate, produced in ISO-certified clean-room facilities under sterile laboratory conditions to ensure high purity and reproducibility.

Chemical Background / Research Profile

The chemical formula of N-Acetyl Epitalon Amidate is C₁₆H₂₄N₆O₉, with a molecular weight of approximately 432.4 g/mol.

This modified tetrapeptide is an analogue of naturally occurring Epitalon and is widely used in molecular and cellular research exploring telomerase activation, protein synthesis, and gene expression regulation in vitro.

In laboratory studies, N-Acetyl Epitalon Amidate is used to:

• Examine peptide stability and degradation kinetics compared with unmodified Epitalon.

• Investigate enzyme resistance and peptide half-life in cell culture systems.

• Study DNA repair processes, cellular ageing, and gene regulation pathways under controlled research conditions.

• Model amino acid modification effects on short peptide stability and solubility.

Because of its dual N- and C-terminal modification, the NAC form provides researchers with a more stable reference compound for long-term biochemical and structural studies.

Purity and Quality Assurance

Permagainz N-Acetyl Epitalon Amidate (NAC) is manufactured to ≥ 98 % purity, validated through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).

All production is conducted under Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) standards in ISO-accredited laboratories.

Each vial is sterile-sealed, batch-numbered, and supplied with a Certificate of Analysis (CoA) confirming molecular structure, purity, and expiry date, ensuring traceability and regulatory compliance for research documentation.

Laboratory Handling and Storage

• Store at 2–8 °C, away from light and humidity.

• For long-term preservation, freezing at –20 °C is recommended.

• Allow vial to reach ambient temperature before opening to prevent condensation.

• Reconstitute under aseptic conditions using sterile bacteriostatic water or another suitable laboratory-grade solvent.

• Avoid repeated freeze–thaw cycles and discard unused material according to institutional chemical waste procedures.

Researchers should always wear appropriate PPE (gloves, lab coat, protective eyewear) and handle all materials in authorised laboratory environments.

Safety, Compliance and Restrictions

N-Acetyl Epitalon Amidate is not a medicinal product, not approved for human or veterinary use, and must not be consumed, injected, or used for therapeutic or diagnostic purposes.

It is supplied strictly for scientific and in-vitro research by qualified professionals.

Permagainz complies fully with MHRA, REACH, and COSHH laboratory safety and documentation standards for non-medicinal research materials.

By combining analytical precision, consistent batch quality, and transparent documentation, Permagainz ensures its N-Acetyl Epitalon Amidate (NAC form) 5 mg meets the rigorous standards demanded for advanced peptide stability and molecular biology research.