PEG-MGF 2MG

Permagainz PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, pegylated peptide analogue of IGF-1 Ec (Mechano Growth Factor) supplied exclusively for in-vitro and laboratory research.

This modified peptide is engineered to extend molecular half-life and stability through the addition of a polyethylene glycol (PEG) chain, allowing researchers to study growth factor signalling, protein synthesis, and cellular regeneration mechanisms under controlled laboratory conditions.

Each vial contains 2 mg of lyophilised PEG-MGF, produced in ISO-certified facilities to ensure analytical consistency, purity, and reproducibility.

Chemical Background / Research Profile

The chemical formula of PEG-MGF varies depending on the PEG chain length but is based on the IGF-1 Ec splice variant sequence, with a molecular weight of approximately 3,300–8,000 g/mol depending on conjugation.

It is a post-transcriptional product of the IGF-1 gene, containing an additional E-peptide segment that plays a regulatory role in cell repair and growth mechanisms in experimental models.

In research applications, PEG-MGF is used to:

• Study IGF-1 receptor activation and downstream signalling pathways such as PI3K/AKT and MAPK.

• Investigate peptide pharmacokinetics and stability enhancement through pegylation.

• Examine cell proliferation, differentiation, and tissue remodelling in in-vitro models.

• Compare biochemical performance between MGF and its pegylated analogue.

The PEG modification reduces enzymatic degradation and enhances molecular stability, allowing for more consistent receptor-binding assays and long-term in-vitro studies.

Purity and Quality Assurance

Permagainz PEG-MGF is manufactured to ≥ 98 % purity, verified by High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).

All production processes are carried out in ISO-accredited clean-room laboratories adhering to Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) standards.

Each vial is sealed under sterile conditions and supplied with a Certificate of Analysis (CoA) confirming batch number, structure, purity, and expiry date to ensure full traceability and research compliance.

Laboratory Handling and Storage

• Store at 2–8 °C, away from direct sunlight and moisture.

• For long-term storage, freezing at –20 °C is recommended.

• Allow the vial to reach room temperature before opening to prevent condensation.

• Reconstitute with sterile bacteriostatic water or other laboratory-grade solvent under aseptic conditions.

• Avoid repeated freeze–thaw cycles and dispose of unused solution in accordance with institutional biosafety procedures.

Researchers should handle PEG-MGF in clean laboratory environments using appropriate PPE (gloves, protective eyewear, and lab coat).

Safety, Compliance and Restrictions

PEG-MGF is not approved for human or veterinary use, not a medicinal product, and must not be administered, ingested, or used for diagnostic or therapeutic purposes.

It is supplied strictly for scientific and in-vitro research by qualified professionals in authorised facilities.

Permagainz operates in compliance with MHRA, REACH, and COSHH safety regulations governing non-medicinal chemical substances.

All materials are batch-tested, traceable, and provided with full documentation to ensure research integrity and reproducibility.

Through rigorous analytical validation, sterile production, and transparent documentation,

Permagainz provides researchers with a consistent, high-purity PEG-MGF 2 mg product suitable for advanced studies in growth factor signalling, protein synthesis, and peptide stability enhancement.