PT‑141 (Bremelanotide) – 10mg

Permagainz PT-141, also known as Bremelanotide, is a synthetic peptide analogue supplied strictly for in-vitro and laboratory research.

It is a derivative of the melanocortin family of peptides, originally developed from α-melanocyte-stimulating hormone (α-MSH), and is studied primarily for its selective activity at melanocortin receptors (MC3R and MC4R).

Each vial contains 10 mg of lyophilised PT-141, produced in ISO-accredited clean-room facilities under sterile conditions to ensure exceptional purity, accuracy, and batch consistency for scientific use.

Chemical Background / Research Profile

The chemical formula of PT-141 is C₅₀H₆₈N₁₄O₁₀, with a molecular weight of approximately 1,024 g/mol.

It is a cyclic heptapeptide derived from Melanotan II, modified to enhance receptor selectivity and stability for receptor-binding studies.

In laboratory environments, PT-141 is used to investigate:

• Melanocortin receptor activation and selectivity, particularly MC3R and MC4R.

• Signal transduction pathways involved in G-protein-coupled receptor (GPCR) function.

• Structure–activity relationships (SARs) between cyclic peptides and receptor affinity.

• Peptide stability and degradation in biological simulation models.

Its cyclic structure provides enhanced conformational rigidity and proteolytic resistance, making it a reliable reference compound in research exploring neuropeptide signalling and melanocortin system biology.

Purity and Quality Assurance

Each batch of Permagainz PT-141 is verified to ≥ 98 % purity, confirmed through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).

All production follows Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) standards within ISO-certified environments.

Each vial is sterile-sealed and accompanied by a Certificate of Analysis (CoA) detailing batch number, purity level, molecular weight confirmation, and expiry date, ensuring full traceability for research documentation.

Laboratory Handling and Storage

• Store at 2–8 °C, away from direct light and moisture.

• For long-term storage, keep frozen at –20 °C.

• Allow vial to reach ambient temperature before opening to prevent condensation.

• Reconstitute under aseptic conditions using sterile bacteriostatic water or another suitable laboratory-grade solvent.

• Avoid repeated freeze–thaw cycles.

• Dispose of unused material according to institutional biosafety and chemical waste procedures.

Researchers must wear appropriate PPE (gloves, coat, and protective eyewear) and conduct all procedures in controlled laboratory environments.

Safety, Compliance and Restrictions

PT-141 (Bremelanotide) is not a medicinal product, not approved for human or veterinary use, and must not be injected, ingested, or used for diagnostic or therapeutic purposes.

It is supplied strictly for in-vitro and scientific research only.
Permagainz operates in full compliance with MHRA, REACH, and COSHH standards regulating the supply and handling of non-medicinal research materials.

Through rigorous analytical testing, documentation transparency, and adherence to international laboratory standards,

Permagainz provides researchers with PT-141 10 mg of exceptional quality for studies relating to melanocortin receptor pharmacology, cyclic peptide design, and cellular signalling.