Semax – 5mg

Permagainz Semax is a synthetic heptapeptide analogue supplied strictly for in-vitro and laboratory research.

It is derived from a fragment of adrenocorticotropic hormone (ACTH 4–10) and has been structurally modified to enhance molecular stability and resistance to enzymatic breakdown during experimental procedures.

Semax is used in molecular and neurobiological studies investigating peptide–receptor signalling, gene expression, and neurotrophic factor regulation under controlled research conditions.

Each vial contains 5 mg of lyophilised Semax, produced under ISO-accredited clean-room conditions to ensure reproducibility, purity, and analytical reliability.

Chemical Background / Research Profile

The chemical formula of Semax is C₃₇H₅₁N₉O₁₀, with a molecular weight of approximately 753.9 g/mol.

It is a heptapeptide derived from ACTH (adrenocorticotropic hormone), modified with a Pro–Gly–Pro extension at the C-terminus to improve structural stability.

In laboratory settings, Semax is used to:

• Examine neuropeptide receptor binding and intracellular signalling mechanisms.

• Study gene regulation related to neuroplasticity and peptide expression.

• Explore oxidative stress responses and peptide stability under variable laboratory conditions.

• Evaluate enzyme resistance and peptide degradation kinetics compared with unmodified ACTH fragments.

Due to its well-defined sequence and predictable structural behaviour, Semax is a valuable research compound in studies of neuropeptide biochemistry and cellular regulation.

Purity and Quality Assurance

All Permagainz research peptides are verified to ≥ 98 % purity, confirmed by High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).

Manufacturing follows Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) within ISO-accredited facilities.

Each vial is sterile-sealed and supplied with a Certificate of Analysis (CoA) confirming batch number, molecular structure, purity, and expiry date to ensure full traceability and documentation compliance.

Laboratory Handling and Storage

• Store at 2–8 °C, protected from light and humidity.

• For long-term storage, freezing at –20 °C is recommended.

• Allow vial to reach ambient temperature before opening to prevent condensation.

• Reconstitute under aseptic conditions using sterile bacteriostatic water or an equivalent laboratory-grade solvent.

• Avoid repeated freeze–thaw cycles and dispose of unused solutions according to institutional biosafety guidelines.

Researchers should handle all peptide materials wearing appropriate PPE (gloves, coat, and protective eyewear) within authorised laboratory facilities.

Safety, Compliance and Restrictions

Semax is not a medicinal product, not for human or veterinary use, and must not be administered, ingested, or used for diagnostic or therapeutic purposes.

It is supplied solely for scientific and in-vitro research.

Permagainz complies fully with MHRA, REACH, and COSHH regulations governing the handling and distribution of non-medicinal research chemicals.

All materials are batch-tested, documented, and traceable to ensure complete regulatory and scientific transparency.

Through rigorous quality control, sterile manufacturing, and validated analytical methods, Permagainz provides Semax 5 mg as a dependable research compound suitable for studies focused on peptide signalling, neuropeptide regulation, and cellular adaptation.