TB500 – 5MG

ermagainz TB-500 is a synthetic research peptide representing a fragment of the naturally occurring Thymosin Beta-4 (Tβ4) protein. It is supplied strictly for in-vitro and laboratory research and is used to investigate actin regulation, cell migration, and tissue repair mechanisms in controlled experimental environments.

Each vial contains 5 mg of lyophilised TB-500, produced under ISO-certified clean-room conditions to ensure high purity, analytical consistency, and reproducibility across research studies.

Chemical Background / Research Profile

The chemical formula of TB-500 is C₂₁₂H₃₅₀N₅₆O₇₈S, with a molecular weight of approximately 4963.4 g/mol.

This synthetic peptide is based on a specific amino acid sequence found in the Thymosin Beta-4 protein, which plays an essential role in cellular structure and motility.

In laboratory settings, TB-500 is studied to:

• Investigate actin polymerisation and cytoskeletal organisation.

• Examine angiogenesis, cell migration, and wound healing processes in vitro.

• Model protein synthesis and tissue remodelling mechanisms.

• Assess peptide stability and degradation kinetics compared to other thymosin-derived analogues.

Due to its sequence homology with the natural actin-binding domain, TB-500 is widely used as a reference compound in studies focusing on cellular structure, repair, and peptide signalling.

Purity and Quality Assurance

Each batch of Permagainz TB-500 is manufactured to ≥ 98 % purity, validated using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).

Production adheres to Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) within ISO-accredited facilities.

Each vial is sterile-sealed and accompanied by a Certificate of Analysis (CoA) confirming molecular structure, purity, batch number, and expiry date for full traceability and research compliance.

Laboratory Handling and Storage

• Store at 2–8 °C, protected from direct light and moisture.

• For extended storage, freezing at –20 °C is recommended.

• Allow the vial to reach ambient temperature before opening to prevent condensation.

• Reconstitute under aseptic conditions using sterile bacteriostatic water or an appropriate laboratory-grade solvent.

• Avoid repeated freeze–thaw cycles and discard unused material according to institutional safety protocols.

Researchers must wear appropriate PPE (gloves, lab coat, and protective eyewear) and handle all peptide materials within authorised laboratory environments.

Safety, Compliance and Restrictions

TB-500 is not a medicinal product, not approved for human or veterinary use, and must not be injected, ingested, or applied for therapeutic or diagnostic purposes.

It is supplied exclusively for in-vitro and scientific research.

Permagainz operates in full compliance with MHRA, REACH, and COSHH regulations covering non-medicinal research chemicals.

All peptides are batch-tested, traceable, and documented to ensure scientific integrity and regulatory compliance.

Through precise synthesis, stringent quality control, and transparent documentation, Permagainz provides TB-500 5 mg as a reliable, high-purity peptide ideal for advanced research into cellular regeneration, cytoskeletal biology, and actin-binding mechanisms.