Tesamorelin – 5mg

Permagainz Tesamorelin is a synthetic 44-amino-acid peptide analogue of growth hormone–releasing hormone (GHRH), supplied strictly for in-vitro and laboratory research.

This peptide is designed to reproduce the biological activity of endogenous GHRH, allowing scientists to investigate pituitary receptor activation, growth hormone (GH) secretion models, and cell-signalling pathways under controlled research conditions.

Each vial contains 5 mg of lyophilised Tesamorelin, produced under ISO-accredited clean-room standards to ensure purity, reproducibility, and analytical integrity.

Chemical Background / Research Profile

The chemical formula of Tesamorelin is C₂₂₁H₃₆₆N₇₂O₆₇S, with a molecular weight of approximately 5135 g/mol.

It is a stable, synthetic form of human growth hormone–releasing factor (1–44), modified with a trans-3-hexenoic acid group at the N-terminus to enhance resistance to enzymatic degradation and extend half-life in laboratory models.

In research settings, Tesamorelin is employed to:

• Study GHRH receptor (GHRHR) binding and signal transduction in cultured pituitary cells.

• Examine GH secretion dynamics and feedback regulation under in-vitro conditions.

• Evaluate peptide stability, enzymatic degradation resistance, and structure–activity relationships.

• Compare receptor selectivity and response between native GHRH and its synthetic analogues.

Because of its structural similarity to endogenous GHRH and its increased molecular stability, Tesamorelin serves as a valuable reference compound in endocrine and biochemical research focused on peptide-mediated hormonal regulation.

Purity and Quality Assurance

Every batch of Permagainz Tesamorelin is manufactured to ≥ 98 % purity, validated through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).

Production is conducted according to Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) in ISO-certified facilities.

Each vial is sterile-sealed, batch-coded, and supplied with a Certificate of Analysis (CoA) verifying molecular structure, purity, and expiry date for full traceability and compliance with research documentation standards.

Laboratory Handling and Storage

• Store at 2–8 °C, protected from light and moisture.

• For long-term storage, freezing at –20 °C is recommended.

• Allow vial to reach ambient temperature before opening to avoid condensation.

• Reconstitute using sterile bacteriostatic water or another suitable laboratory-grade solvent under aseptic conditions.

• Avoid repeated freeze–thaw cycles and dispose of unused material according to institutional biosafety and chemical-waste procedures.

Researchers should always wear appropriate PPE (gloves, coat, and protective eyewear) and handle all peptide compounds within authorised laboratory environments.

Safety, Compliance and Restrictions

Tesamorelin is not a medicinal product, not approved for human or veterinary use, and must not be administered, ingested, or used for diagnostic or therapeutic purposes.

It is supplied exclusively for scientific and in-vitro research.

Permagainz complies fully with MHRA, REACH, and COSHH regulations governing non-medicinal research chemical supply.

All peptides are batch-tested, traceable, and supplied with transparent documentation for legitimate laboratory use.

Through precise synthesis, strict quality control, and regulatory compliance, Permagainz provides Tesamorelin 5 mg as a dependable research-grade peptide for the study of GHRH receptor activation, growth hormone secretion, and endocrine peptide signalling.