MK‑677 (Ibutamoren) – 12.5mg

Permagainz MK-677 (Ibutamoren) is a non-peptidic growth hormone secretagogue supplied strictly for in-vitro and laboratory research use.

This compound is studied for its role as a ghrelin receptor (GHS-R1a) agonist, making it a valuable reference material for researchers exploring endocrine regulation, growth hormone (GH) release, and energy metabolism pathways under controlled laboratory conditions.

Each vial contains 12.5 mg of MK-677, produced in ISO-accredited clean-room facilities to ensure consistency, purity, and analytical traceability.

Chemical Background / Research Profile

The chemical formula of MK-677 is C₂₇H₃₆N₄O₅S, with a molecular weight of approximately 528.7 g/mol.

It belongs to the class of growth hormone secretagogues (GHSs) and functions as a selective agonist of the ghrelin receptor, which regulates the release of GH and IGF-1 in biological systems.

In research environments, MK-677 is commonly used to:

• Examine ghrelin receptor binding and signal transduction mechanisms.

• Investigate peptide-independent GH secretagogue activity.

• Study metabolic and hormonal pathways related to GH release.

• Assess ligand selectivity, receptor affinity, and molecular stability in vitro.

Because of its high oral bioavailability and non-peptidic structure, MK-677 provides researchers with a practical model for studying endocrine receptor activation and metabolic regulation under laboratory conditions.

Purity and Quality Assurance

Permagainz MK-677 is verified to ≥ 98 % purity, confirmed through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) testing.

Production adheres to Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) standards within ISO-certified facilities.

Each vial is sterile-sealed, batch-numbered, and supplied with a Certificate of Analysis (CoA) confirming purity, structure, batch code, and expiry date for full documentation compliance.

Laboratory Handling and Storage

• Store at 20–25 °C in a dry, dark environment.

• Protect from heat, humidity, and light exposure.

• Dissolve or dilute using analytical-grade solvents under aseptic conditions.

• Avoid repeated freeze–thaw cycles and contamination.

• Dispose of any unused material in accordance with institutional safety and COSHH guidelines.

Researchers must wear appropriate PPE (gloves, lab coat, and protective eyewear) and handle all compounds in authorised laboratory environments.

Safety, Compliance and Restrictions

MK-677 (Ibutamoren) is not a pharmaceutical, not approved for human or veterinary use, and must not be consumed, injected, or used for diagnostic or therapeutic purposes.

It is supplied exclusively for scientific and in-vitro research by qualified professionals.

Permagainz operates in full compliance with MHRA, REACH, and COSHH regulations governing non-medicinal research substances.

All products are batch-tested, traceable, and provided with transparent documentation to ensure safe and legitimate laboratory use.

Through precise formulation, verified purity, and scientific accuracy, Permagainz supplies MK-677 12.5 mg as a dependable compound for advanced research into endocrine receptor signalling, ghrelin-mediated pathways, and growth hormone secretagogue mechanisms.